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This clarifies why 1 lorazepam dose, Even with its shorter serum 50 %-lifetime, has a lot more extended peak consequences than an equal diazepam dose.[ninety nine] Lorazepam is promptly conjugated at its three-hydroxy group into lorazepam glucuronide and that is then excreted within the urine. Lorazepam glucuronide has no demonstrable CNS exercise