If regular therapy is continued for for a longer period than four to six months, dose boosts could possibly be essential to preserve effects, but procedure-resistant symptoms may perhaps in truth be benzodiazepine withdrawal signs.[seventy nine] Resulting from the event of tolerance towards the anticonvulsant outcomes, benzodiazepines are normally
This clarifies why 1 lorazepam dose, Even with its shorter serum 50 %-lifetime, has a lot more extended peak consequences than an equal diazepam dose.[ninety nine] Lorazepam is promptly conjugated at its three-hydroxy group into lorazepam glucuronide and that is then excreted within the urine. Lorazepam glucuronide has no demonstrable CNS exercise
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